Pathway analysis of up-regulated genes from HOS/143B and SaOS-2/LM7 models. Top 10 significant pathways identified by MetaCore using all the significantly up-regulated genes from (A) HOS/143B and (b) SaOS-2/LM7 models. Only one common pathway, the “Development_WNT signaling pathway. Part 2”, was identified in the top 10 significant pathways between the two models. Bars quantify the –log (p-value) indicating the enrichment of the individual pathways identified. False discovery rate (FDR) is calculated for all identified pathways and a cutoff of FDR < 0.05 is set to define pathways as significant. Asterisks denote significant pathways shown.
Flores et al. BMC Systems Biology 2012 6:50 doi:10.1186/1752-0509-6-50