FBrAtio predictions using the iCAC490 model at various levels of CoAT knockdown and AAD over-expression. Shown are predictions of growth (x10) (blue), acetone (cyan), butanol (red), and ethanol (green) production during solventogenesis (SPF = 5). The following flux ratios were applied: (i) f(rTHL):f(rAAD_1), (ii) f(rCoAT):f(rBHBD), (iii) f(rPTB): f (rAAD_2), and (iv) f(rADD_3):f(rAAD_1). The following were held constant: (i) glucose uptake rate of , (ii) constraints listed in Table 1, (iii) f(rTHL):f(rPTA) = 2, (iv) f(CO2export):f(CO2conversion) = 5, (v) f(rPFO):f(rLDH) = 10, and (vi) f(rCoAT, butyrate):f(rCoAT, acetate) = 0.63.
McAnulty et al. BMC Systems Biology 2012 6:42 doi:10.1186/1752-0509-6-42