Open Access Highly Accessed Research article

A network perspective on metabolic inconsistency

Nikolaus Sonnenschein1*, José Felipe Golib Dzib2, Annick Lesne23, Sebastian Eilebrecht24, Sheerazed Boulkroun5, Maria-Christina Zennaro56, Arndt Benecke24 and Marc-Thorsten Hütt1

Author Affiliations

1 School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, 28759 Bremen, Germany

2 , Institut des Hautes Études Scientifiques — Centre National de la Recherche Scientifique, Bures-sur-Yvette, France

3 LPTMC CNRS UMR 7600, Université Pierre et Marie Curie-Paris 6, 4 place Jussieu75252 Paris Cedex 05, France

4 Vaccine Research Institute, INSERM U955, Institut Mondor de Recherche Biomédicale, Université Paris-Est Créteil, Créteil, France

5 INSERM, U970, Paris Cardiovascular Research Center, Paris, France

6 , University Paris Descartes, Paris, France

For all author emails, please log on.

BMC Systems Biology 2012, 6:41  doi:10.1186/1752-0509-6-41

Published: 14 May 2012

Additional files

Additional file 1:

Text S1. Supporting information, including Supplemental Figures S1–7 and Tables S1–2 [8-14,16,21-24,26-28].

Format: PDF Size: 1.8MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Pathway map SIaa. Amino acid biosynthesis pathways. The map depicts the usage patterns and inconsistency contributions for the overall contributions (page i), control (page ii), LIG (page iii), and HIG (page iv). The thickness and color of a reaction edge corresponds to the usage frequency and the contribution strength, respectively. The pathway maps have been obtained from the BIGG database [17].

Format: PDF Size: 1.5MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

Pathway map SIcarb. Central metabolism and carbohydrate pathways (see also Additional file 2.

Format: PDF Size: 1.3MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

Pathway map SIlip. Lipid metabolism pathways (see also Additional file 2.

Format: PDF Size: 2.7MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 5:

Pathway map SIvit. Vitamins and cofactor pathways (see also Additional file 2.

Format: PDF Size: 1MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data