Figure 6.

Full and coarse-grained mechanisms of a gene network. Cartoon illustrating the full and coarse-grained networks for the gene network with a single negative feedback loop. The reduced, coarse-grained network is obtained from the full network under conditions of timescale separation, i.e., transients in the concentrations of all enzyme, enzyme complex, gene and gene complex species decay much faster than transients in the concentrations of mRNA and protein

Thomas et al. BMC Systems Biology 2012 6:39   doi:10.1186/1752-0509-6-39
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