Additional file 4.

Figure S2 Gene Association rewrite from S. cerevisiae reactions to Y. lipolytica. Pipeline for gene-association rewriting, as part of the projection of Y. lipolytica iNL895 model. From the 4 ortholog maps provided by different methods, a map of votes of possible ortholog mappings is created. Then, from the scaffold model, we extracted gene associations for each reaction, and re-wrote them based on our map of homologs (e.g.: Reaction1: (SourceGene1 or SourceGene2) ↔ (TargetGene1)). The new reactions, this time associated with Y. lipolytica genes, constituted the base of the reconstructed model.

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Loira et al. BMC Systems Biology 2012 6:35   doi:10.1186/1752-0509-6-35