Spoke modules. (A) Deterministic hierarchical model. (B) Spoke model. (C) The connection of the top 6 best connected nuclear proteins and their neighbors displays a spoke-like topology. (D) Spoke-like protein complexes. (E) Gene srb4 is a member of clique and a member of spoke-like topology.
Hao et al. BMC Systems Biology 2012 6:34 doi:10.1186/1752-0509-6-34