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Open Access Research article

Revisiting the variation of clustering coefficient of biological networks suggests new modular structure

Dapeng Hao1*, Cong Ren2 and Chuanxing Li1*

Author Affiliations

1 College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China

2 The Second Department of Orthopedics, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China

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BMC Systems Biology 2012, 6:34  doi:10.1186/1752-0509-6-34

Published: 1 May 2012

Additional files

Additional file 1:

Figure S1. Clustering coefficient distribution. (A) C(k) curves of protein interaction network and (B)genetic interaction network, as well as their random counterparts of same degree distribution (generated by randomly rewiring the edges, black circles).

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Additional file 2:

Figure S2. The variation of C(k) of protein interaction network (red circles) and stringent but uncorrelated random network (black circles). The random network and the protein interaction network have at least 30% of edges overlapped.

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Additional file 3:

Figure S3. The functional module associated to cell wall organization is built by connecting several spokes in yeast interactome.

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