Kaplan-Meier curves generated according to values of the PDGF pathway. Panel (a) shows the KM curve generated using the TCGA dataset. Panels (b) and (c) show curves from Duke Dataset #1 and #2 respectively. Across the three panels, Group1 (blue line), which is affiliated with better prognosis, shows lower pathway activity values and Group2 (green line) shows higher pathway activity values. The affiliation of pathway metric levels with prognosis is highly robust in this case, as it shows low p-values and consistent behavior across datasets.
Ben-Hamo and Efroni BMC Systems Biology 2012 6:3 doi:10.1186/1752-0509-6-3