Table 2

The list of prioritized synthetic lethal targets

Gene#1

Enzyme name

Druggability

No. of drugs

Gene#2

Enzyme name

Druggability

No. of drugs

Avg. druggability


LmjF27.2050

ribonucleoside-diphosphate reductase small chain

1

13

LmjF22.1290

ribonucleoside-diphosphate reductase small chain

1

13

1


LmjF06.0860

dihydrofolate reductase-thymidylate synthase

1

76

LmjF21.1210

thymidine kinase

0.8

10

0.9


LmjF20.0100

phosphoglycerate kinase

0.8

7

LmjF24.0850

triose-phosphate isomerase

0.8

7

0.8


LmjF24.0850

triose-phosphate isomerase

0.8

7

LmjF30.3380

phosphoglycerate kinase

0.5

7

0.65


LmjF04.0960

adenylate kinase

0.5

5

LmjF34.0110

adenylate kinase

0.8

4

0.65


LmjF30.3520

S-adenosylmethionine synthetase

0.6

17

LmjF30.3500

S-adenosylmethionine synthetase

0.6

17

0.6


LmjF05.0510

F-type H+-transporting ATPase alpha chain

0.5

2

LmjF05.0500

F-type H+-transporting ATPase alpha chain

0.5

2

0.5


LmjF25.1180

F-type H+-transporting ATPase beta chain

0.5

3

LmjF25.1170

F-type H+-transporting ATPase beta chain

0.5

3

0.5


Chavali et al. BMC Systems Biology 2012 6:27   doi:10.1186/1752-0509-6-27

Open Data