Table 1

The list of prioritized L. major targets

L. major targets

Enzyme name

E.C.

Metabolic pathway(s)

Sub-cellular localization(s)†

Druggability

Growth defect*

No. of drugs


LmjF04.0580

spermidine synthase

2.5.1.16

methionine metabolism

cytosol

0.8

100% (L)

3


LmjF05.0350

trypanothione reductase

1.8.1.12

trypanothione metabolism

glycosome

0.9

100% (L)

45


LmjF05.0830

methylthioadenosine phosphorylase

2.4.2.28

methionine metabolism

cytosol

0.8

100% (L)

15


LmjF06.0650

lanosterol synthase

5.4.99.7

steroid biosynthesis

ER

0.6

100% (L)

3


LmjF11.1100

sterol 14-demethylase

1.14.13.70

steroid biosynthesis

ER

0.8

100% (L)

133


LmjF12.0280

ornithine decarboxylase

4.1.1.17

urea cycle and metabolism of amino groups

cytosol

1

100% (L)

40


LmjF13.1620

squalene monooxygenase

1.14.99.7

steroid biosynthesis

ER

0.8

100% (L)

14


LmjF18.0020

diphosphomevalonate decarboxylase

4.1.1.33

steroid biosynthesis

glycosome/cytosol

0.6

100% (L)

5


LmjF22.1360

dimethylallyltranstransferase

geranyltranstransferase

2.5.1.1

2.5.1.10

steroid biosynthesis

glycosome/cytosol

0.8

100% (L)

11


LmjF25.1120

aldehyde dehydrogenase

1.2.1.3

many pathways

mitochondria

1

> 30% (GR)

28


LmjF30.3190

hydroxymethylglutaryl CoA reductase

1.1.1.34

steroid biosynthesis

glycosome/mitochondria

0.8

100% (L)

29


LmjF31.2940

squalene synthase

2.5.1.21

steroid biosynthesis

glycosome/cytosol

0.8

100% (L)

9


LmjF32.1580

phosphomannose isomerase

5.3.1.8

fructose and mannose metabolism

cytosol

0.6

100% (L)

5


LmjF33.2720

beta-ketoacyl-acyl-carrier-protein synthase I

2.3.1.41

fatty acid biosynthesis

mitochondria

0.7

100% (L)

5


LmjF35.3340

phosphogluconate dehydrogenase

1.1.1.44

pentose phosphate pathway

cytosol

0.8

100% (L)

13


* (L) Lethal, (GR) Growth-reducing; † (ER) Endoplasmic Reticulum

Chavali et al. BMC Systems Biology 2012 6:27   doi:10.1186/1752-0509-6-27

Open Data