Pipelines for prioritization of targets and drugs. The funnel diagrams in panels A and B depict the specific datasets, tools and cutoffs used in the process of prioritization. Panel A presents the prioritization scheme that includes single gene deletions as a constraint, while Panel B presents the prioritization scheme that includes double gene deletions (or synthetic lethality) as a constraint.
Chavali et al. BMC Systems Biology 2012 6:27 doi:10.1186/1752-0509-6-27