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Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease

Arvind K Chavali1, Anna S Blazier1, Jose L Tlaxca1, Paul A Jensen1, Richard D Pearson23 and Jason A Papin14*

Author Affiliations

1 Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA

2 Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA

3 Department of Pathology, University of Virginia, Charlottesville, VA, USA

4 Mail: Box 800759, Health System, University of Virginia, Charlottesville, VA, 22908, USA

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BMC Systems Biology 2012, 6:27  doi:10.1186/1752-0509-6-27

Published: 27 April 2012

Additional files

Additional file 1:

In this supplement, additional experimental data, analysis and network characteristics are presented that are not already described in the main article [11,17-22,54].

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Additional file 2:

In this supplement, initial gene-drug associations, various metric scores for L. major genes, synthetic lethal predictions, toxicity ratings for drugs, and list of drugs removed from MetDP analysis are presented.

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