Initial estimated state bounds. The true state values resulting from x1(t0) = x2 (t0) = 50 and p = [1, 0.01, 1, 0.02] are shown in grey (x*). The initial measurement set is shown as uncertainty bounds in x1 at t = 2, 4, and 6 . Recall that measurements are only available for x1. The dashed lines show the results of the uncertainty propagation of the estimated parameter boxes in Figure 2 (xest). The dotted lines show the positions of candidate times points (tj).
Marvel and Williams BMC Systems Biology 2012 6:21 doi:10.1186/1752-0509-6-21