Explaining conflictions in SM overexpression experiments. (a) shows a scenario where the overexpression of SM may cause increased fusion. (b) shows a scenario where the overexpression of SM may cause decreased fusion. The bifurcation behavior of the neuronal SM-SNARE network motif provides an explanation for conflicting observations in SM protein overexpression experiments.
Xia et al. BMC Systems Biology 2012 6:19 doi:10.1186/1752-0509-6-19