Table 1

PPI z-score and the coverage of gene sets involved in regulatory motifs

Single-regulation

Co- regulation

Crosstalk

Independent


TF-TF


z-score

62.17

62.10

-0.80

-27.32


coverage

16.19%

4.31%

96.65%

83.81%


z-score*

56.43

51.37

11.37

-15.14


coverage*

6.72%

0.92%

70.60%

93.28%


miRNA-miRNA


z-score

35.37

38.15

1.52

-20.79


coverage

25.68%

9.14%

96.60%

74.32%


z-score*

34.74

32.16

14.37

-12.08


coverage*

10.79%

2.15%

69.08%

89.21%


TF-miRNA


z-score

-

62.44

-0.09

-55.91


coverage

-

6.65%

97.42%

73.52%


z-score*

-

47.94

15.71

-33.91


coverage*

-

1.18%

70.49%

88.31%


*The asterisk represents the filtered values. The upper limit of target gene size for filtration of TF-TF, miRNA-miRNA, and TF-miRNA motifs is 781, 789, and 789, respectively.

*The coverage represents the ratio of gene pairs in regulatory motifs to all possible gene pairs in HPRD PIN.

Lin et al. BMC Systems Biology 2012 6:18   doi:10.1186/1752-0509-6-18

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