Figure summarizing the functional dependence of the co-regulated genes on the active signaling pathways of endoderm induction. CER and HNF6 are favoured by High activin and PI3KI, WNT3A, FGF2 while HNF4α and HNF6 are favoured by High activin, WNT3A and PI3KI. Combining the early and late stages, high activin with PI3KI and WNT3A together is an effective strategy for endoderm differentiation.
Mathew et al. BMC Systems Biology 2012 6:154 doi:10.1186/1752-0509-6-154