Work-flow for the entire analysis from data collection to identification of robust biclusters. In short, we start with the qRT-PCR data and perform bootstrap with re-sampling to obtain 1000 pseudo-datasets. Each of these datasets is subjected to biclustering analysis to obtain the most coherent pattern in each dataset. The resulting biclusters are then analyzed for the most repeated subsets of biclusters.
Mathew et al. BMC Systems Biology 2012 6:154 doi:10.1186/1752-0509-6-154