Prediction of ErbB1 tyrosine kinase as a possible off-target of torcetrapib. (A) Docked complex of ErbB1 (PDB code 3BEL) and compound POX in the best docking pose. (B) Docked complex of ErbB1 and torcetrapib in the best docking pose. Compound POX and torcetrapib were in the stick representation, whilst the amino acid residues of ErbB1 tyrosine kinase were displayed by solid ribbon style in the line representation. C, H, O, N and F were colored with gray, white, red, blue and brown, respectively.
Fan et al. BMC Systems Biology 2012 6:152 doi:10.1186/1752-0509-6-152