Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach
1 State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University and Institute of System Biomedicine, Peking University, No.38 Xueyuan Road, Beijing, 100191, China
2 Department of Cardiology, Peking University People’s Hospital, No.11 Xizhimen South Street, Beijing, 100044, China
3 Department of Pharmacy, Xi’an Children’s Hospital, No.69 Xijuyuan road, Xi’an, 710003, China
BMC Systems Biology 2012, 6:152 doi:10.1186/1752-0509-6-152Published: 10 December 2012
Additional file 1:
List of significant over-expressed genes by Significance Analysis of Microarray (SAM).
Format: XLSX Size: 60KB Download file
Additional file 2:
List of raw genes obtained from Human Protein Reference Database (HPRD).
Format: XLSX Size: 1.8MB Download file
Additional file 3:
List of the core gene regulatory networks (GRNs) up-regulated by torcetrapib.
Format: XLSX Size: 11KB Download file