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Open Access Highly Accessed Research article

Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach

Shengjun Fan1, Qiang Geng2, Zhenyu Pan3, Xin Li1, Lu Tie1, Yan Pan1 and Xuejun Li1*

Author Affiliations

1 State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University and Institute of System Biomedicine, Peking University, No.38 Xueyuan Road, Beijing, 100191, China

2 Department of Cardiology, Peking University People’s Hospital, No.11 Xizhimen South Street, Beijing, 100044, China

3 Department of Pharmacy, Xi’an Children’s Hospital, No.69 Xijuyuan road, Xi’an, 710003, China

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BMC Systems Biology 2012, 6:152  doi:10.1186/1752-0509-6-152

Published: 10 December 2012

Additional files

Additional file 1:

List of significant over-expressed genes by Significance Analysis of Microarray (SAM).

Format: XLSX Size: 60KB Download file

Open Data

Additional file 2:

List of raw genes obtained from Human Protein Reference Database (HPRD).

Format: XLSX Size: 1.8MB Download file

Open Data

Additional file 3:

List of the core gene regulatory networks (GRNs) up-regulated by torcetrapib.

Format: XLSX Size: 11KB Download file

Open Data