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Open Access Methodology article

Incremental parameter estimation of kinetic metabolic network models

Gengjie Jia1, Gregory Stephanopoulos2 and Rudiyanto Gunawan3*

Author Affiliations

1 Chemical and Pharmaceutical Engineering, Singapore-MIT Alliance, Singapore, 117576, Singapore

2 Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

3 Institute for Chemical and Bioengineering, ETH Zürich, 8093, Zürich, Switzerland

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BMC Systems Biology 2012, 6:142  doi:10.1186/1752-0509-6-142

Published: 21 November 2012

Additional files

Additional file 1:

Incremental Estimation Code. Additional file 1 contains MATLAB codes for the parameter estimations in the two case studies: branched pathway model and L. lactis pathway model.

Format: ZIP Size: 271KB Download file

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Additional file 2:

Supplementary Tables. Additional file 2 contains the parameter estimation results of the branched pathway model using noise-free data and analytical slopes, the parameter estimates of the two case studies, and the parameter estimation results of five repeated runs.

Format: PDF Size: 233KB Download file

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Open Data