Open Access Research article

Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach

Tatiana A Karelina1*, Kirill V Zhudenkov1, Oleg O Demin1, Dmitry V Svetlichny1, Balaji Agoram23, David Fairman34 and Oleg V Demin1

Author Affiliations

1 Institute for Systems biology SPb, Moscow, Russia

2 Clinical Pharmacology, Pfizer PGRD, Sandwich, UK

3 Now Clinical Pharmacology and DMPK, MedImmune, Cambridge, UK

4 Pharmacokinetics, Dynamics and Metabolism, Pfizer PGRD, Sandwich, UK

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BMC Systems Biology 2012, 6:141  doi:10.1186/1752-0509-6-141

Published: 12 November 2012

Additional files

Additional file 1:

Appendix 1. Derivation of model equations.

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Additional file 2:

Appendix 2. Additional figures.

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