An overview of the cTFBSs and their regulatory effects on the ESCC genes. The figure represents a heat map of cTFBSs that are significantly over-represented in the promoters of the known estrogen response genes in ESCC (columns) mapped to the promoters of the new candidate estrogen response genes in C2A (rows). The red shading depicts the association between the gene promoter and the cTFBSs, while white depicts no association.
Essack et al. BMC Systems Biology 2012 6:135 doi:10.1186/1752-0509-6-135