Open Access Research article

Identification of estrogen responsive genes using esophageal squamous cell carcinoma (ESCC) as a model

Magbubah Essack, Cameron Ross MacPherson, Sebastian Schmeier and Vladimir B Bajic*

Author Affiliations

Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia

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BMC Systems Biology 2012, 6:135  doi:10.1186/1752-0509-6-135

Published: 26 October 2012

Additional files

Additional file 1:

ESCC genes categorized based on ERE predictions and experimental evidence of estrogen responsiveness. Appendix I.xls contains all the 418 ESCC genes tabulated based on ERE predictions and experimental evidence of estrogen responsiveness.

Format: XLS Size: 239KB Download file

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Additional file 2:

TFBS matrices mapped to the promoters of the ESCC genes. Appendix II.xls contains all the TFBS matrices mapped to the promoters of the ESCC genes.

Format: XLSX Size: 10MB Download file

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Additional file 3:

Multiple cTFBSs mapped to the promoters of the ESCC genes. Appendix III.xls contains the number of multiple cTFBS matrices mapped to the promoters of the ESCC genes in categories C1, C2, C3 nad C4.

Format: XLS Size: 61KB Download file

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Additional file 4:

Pathways enriched in the Four ESCC gene categories. Appendix IV.xls contains details of the enriched KEGG pathways in the four gene categories.

Format: XLSX Size: 33KB Download file

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Additional file 5:

The most significant cTFBS. Appendix V.xls contains details of the most significant combination of cTFBSs comprising V$TAXCREB_02, V$AREB6_01, V$CREB_Q3 and V$E2A_Q6.

Format: DOCX Size: 54KB Download file

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Additional file 6:

The significant TFBSs and their associated TFs. Appendix VI.xls contains details of the 137 significant TFBSs and the TFs that bind them.

Format: XLS Size: 572KB Download file

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Additional file 7:

Ranked list of putative estrogen responsive ESCC genes. Appendix VII.xls contains a ranked list of putative estrogen response ESCC genes based on the number of cTFBSs mapped the promoter.

Format: XLS Size: 27KB Download file

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