Additional file 4.
Example of results for the HepG2 real data application. A. Previous knowledge network used for this analysis. B. Example of a trained model obtained in one of the optimization round, with a subset of the simulation results obtained with this network (C). For the networks the color codes are as follows: nodes: green=stimulated, red=inhibited, blue=measured, blue with red stroke=measured and inhibited, dashed stroke=compressed; edges (in the trained model in panel B): green=selected at time 1, blue=selected at time 2, grey=not selected in the trained model. In panel C, black continuous lines=data, dashed blue lines=simulation results obtained with the model in B. The background color reflects the goodness of fit of the model to data: green= the chosen Boolean value is closer to the data than the opposite Boolean value (the darker, the closer), red= the chosen Boolean value is further from the data than the opposite Boolean value (the darker, the further).
Format: PDF Size: 185KB Download file
This file can be viewed with: Adobe Acrobat Reader
Terfve et al. BMC Systems Biology 2012 6:133 doi:10.1186/1752-0509-6-133