(A-F)The response of the model to changes in the intake of dietary cholesterol compared to a published meta-analysis.A) The relationship between mean change in dietary cholesterol (mg/day) and mean change in plasma cholesterol levels (mg/dL) in 167 cholesterol feeding studies published between 1960 and 1999 (McNamara 2000). B-D) The response of the model to changes in dietary cholesterol over a range of time periods. E) Steady-state levels of LDL-C for various different intakes of dietary cholesterol. F) The change in LDL-C levels in response to various different values of the parameter k1(cholesterol ingestion). Results of both E&F were generated from a sensitivity analysis of the model using the software tool Copasi.
Mc Auley et al. BMC Systems Biology 2012 6:130 doi:10.1186/1752-0509-6-130