Figure 4 .
Schematic diagram of the hypothesized Meq-CD30- NF-κB feed forward loop, subcellular localization and phosphorylation status of different isoforms of NF-κB. Schematic diagram of hypothesized Meq-CD30-NF-κB feed forward loop and showing differential expression of NF-κB isoforms (A). Comparison of the amount and sub cellular localization of NF-κB isoforms: circle size proportionately portrays relative protein amount; equal size indicates no differential expression at P < 0.05 (B). In CD30hi lymphocytes most IKKα is phosphorylated at the canonical residues that regulate proteasome-mediated degradation and destabilization, whereas in CD30lo lymphocytes most IKKα and IKKβ is unphosphorylated at these same residues (C).
Kumar et al. BMC Systems Biology 2012 6:123 doi:10.1186/1752-0509-6-123