Table 3

Simulation of varied substrate availability: baseline ATP consumption
βGlucose βOleate βAcetoacetate βLactate <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M15','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M15">View MathML</a> vs <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M16','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M16">View MathML</a>
<a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M17','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M17">View MathML</a> <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M18','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M18">View MathML</a>
0.00 1.00 0.00 0.00 4.1101 0.1626 0.6849
1.00 0.00 0.00 0.00 3.6007 0.6005 0.6576
0.00 0.00 1.00 0.00 3.9269 0.9806 0.2791
0.00 0.00 0.00 1.00 3.8124 1.2701 0.2091
0.79 0.21 0.00 0.00 3.8534 0.3823 0.7334
0.42 0.37 0.09 0.12 3.9830 0.3154 0.7000
0.33 0.19 0.43 0.05 3.9420 0.4536 0.6500
0.20 0.16 0.26 0.38 3.9485 0.5292 0.6000
0.46 0.03 0.46 0.05 3.7757 0.6847 0.5500
0.17 0.09 0.01 0.73 3.8880 0.7020 0.5000
0.20 0.04 0.41 0.35 3.8534 0.7841 0.4500
0.16 0.03 0.33 0.48 3.8448 0.8575 0.4000
0.06 0.05 0.03 0.86 3.8794 0.8942 0.3600
0.02 0.02 0.52 0.44 3.9010 0.9677 0.3000
0.07 0.00 0.07 0.86 3.7930 1.1556 0.2500
0.00 0.00 0.13 0.87 3.8297 1.2247 0.2070

All data is ranked by the calculated efficiency in descending order and given fully for exclusive utilization of each substrate. Results for altered substrate availability are listed by the achieved efficiency with a value of: 0.25, 0.3,0.36, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65 and 0.7. A substrate combination of 79% glucose and 21% oleate to the total substrate uptake rate attained the highest calculated efficiency ( <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M19','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M19">View MathML</a>). Least efficient ( <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M20','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M20">View MathML</a>) was a combination of 13% acetoacetate and 87% lactate. For a complete overview of all results, please see Additional file 8 and 9. <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M21','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M21">View MathML</a> indicates oxygen demand; vs, total substrate uptake rate; and <a onClick="popup('http://www.biomedcentral.com/1752-0509/6/114/mathml/M22','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/6/114/mathml/M22">View MathML</a>, calculated efficiency.

Karlstädt et al.

Karlstädt et al. BMC Systems Biology 2012 6:114   doi:10.1186/1752-0509-6-114

Open Data