Additional file 7.

Definition and overview of constraints for simulations as used in the optimization problems for varied substrate availability. Constraints listed in this table were applied in simulations for varied substrate availability. For all three simulation settings the corresponding target function and applied constraints are given. The simulation settings include, first, simulations of substrate uptake rates for four different substrates and oxygen demands while satisfying a baseline ATP consumption rate. Second, simulations of substrate uptake rates for four different substrates and oxygen demands as under experimental conditions while satisfying the same baseline ATP consumption rate. Finally, simulations of substrate uptake rates for nine different substrates and oxygen demands while satisfying a predefined metabolic target function.

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Karlst├Ądt et al. BMC Systems Biology 2012 6:114   doi:10.1186/1752-0509-6-114