Additional file 6.

Testing functionality of Human heart model. A comparison of the metabolic network to a previously reported genome-scale reconstruction of the human heart [25] was performed. The presented physiological functions of the cardiomyocyte (see Additional file 13) were applied to test the functionality of the partial network of the human heart and compare the performance of both networks. From 110 tested functions 53 were found to have no feasible solution, this included important cellular functions such as the citric acid cycle.

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Karlst├Ądt et al. BMC Systems Biology 2012 6:114   doi:10.1186/1752-0509-6-114