Additional file 11.
Predicted metabolic fluxes of substrate uptake and oxygen demand for fulfilling the metabolic target function in varied substrate availability,. We simulated a varied substrate availability for nine selected substrates, including glucose, palmitate, stearate, oleate, alpha-linoleate, eicosapentaenoate, docosahexaenoate, acetoacetate and lactate. During the simulations, we demanded an ATP expenditure (vATPase) of 21.6 mmol·min−1·(l cell)−1 and metabolic target flux, as specified in Additional file 6. This table lists results for substrate combination for which efficiency values ( ) greater than 0.8 were calculated. Uptake rates for all nine substrates, the resulting total substrate uptake rate and oxygen consumption rate for all simulated substrate compositions which fulfilled the metabolic objective are given. Furthermore solutions for glycogen synthesis and glycogenolysis as determined during simulations are shown.
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Karlstädt et al. BMC Systems Biology 2012 6:114 doi:10.1186/1752-0509-6-114