Illustration of total substrate uptake rate (vs) and oxygen demand () for a fixed glucose supply with (A) β = 0.25 and (B) β = 0.75. The ATP consumption rate (vATPase) were restricted to 21.6 . The panels A.1 and B.1 refer to the oxygen demand ( ) for the given glucose proportion, while panels A.2 and B.2 refer to the total substrate uptake rate (vs). For each panel we marked the optimal substrate composition (*): (A) vGlucose = 25%, vOleate = 64%, vAcetoacetate = 0%, vLactate = 11%, (B) vGlucose = 75%, vOleate = 25%, vAcetoacetate = 0%, vLactate = 0%.
Karlstädt et al. BMC Systems Biology 2012 6:114 doi:10.1186/1752-0509-6-114