Overview of constructing miRNA-target influence (miRTI) network and its application. A. miRTI is constructed by integrating matched miRNA and mRNA expression data with FPI and miRNA-target networks. The influence of a miRNA on its target is based on combining three variables; strength of negative correlation between miRNa and its target, direct influence of miRNA on target partners and indirect influence of miRNA on target through partners. B. After constructing the miRTI, we used it to predict miRNA-patient influence network using elastic-net regression model. The gene expression profile of each PCs is a linear combination of the influence of miRNAs on its targets.
Alshalalfa et al. BMC Systems Biology 2012 6:112 doi:10.1186/1752-0509-6-112