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Balancing speed and accuracy of polyclonal T cell activation: a role for extracellular feedback

Yonatan Savir13, Nir Waysbort2, Yaron E Antebi24, Tsvi Tlusty1 and Nir Friedman2*

Author Affiliations

1 The Simons Center for Systems Biology, Institute for Advanced Studies, Princeton, New Jersey, 08540, USA

2 Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel

3 Department of Systems Biology,, Harvard Medical School Harvard Medical School, Warren Alpert Building, Room 555B 200 Longwood Avenue, Boston, MA, 02115, USA

4 Division of Biology, Caltech, Pasadena, CA, 91125, USA

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BMC Systems Biology 2012, 6:111  doi:10.1186/1752-0509-6-111

Published: 27 August 2012

Additional files

Additional file 1:

Table S1. The parameters of the model. Table S2. Parameters related to the full IL-2R dynamics. Figure S1. Phase space diagrams for the case of a constant induced receptor synthesis rate. Figure S2. Phase space diagrams for the case of a constant IL-2 secretion rate. Figure S3. Variation in the IL-2 secretion rate, s.Figure S4. Variation in the IL-2 degradation rate, d. Figure S5. Variation in the constitutive receptor synthesis rate, gc and in the unbound receptor internalization rate, aU. Figure S6. Variation in the bound receptor internalization rate, aB. Figure S7. Variation in the maximal induced synthesis rate, gf. Figure S8. Variation in the feedback threshold level, Kf. Figure S9. Variation in the Hill coefficient, n. Figure S10. The competition between m1 = 1 and m2 = 0.7. Figure S11. Dynamical orbits of the competition between m = 1 and m = 0.7. Figure S12. One cell fixed points results for the full and effective models. Figure S13. Phase space diagrams of the full and effective models. Figure S14. Two cells with the same m value exhibit a complex time dependent behavior. Figure S15. Interaction of an effector T cell with a regulatory T cell is time dependent. Figure S16. Interaction phase diagrams for an effector T cell that is interacting with a non-secreting T cell. Figure S17. Examples of time dynamics. Figure S18. The distribution of B when the initial number of IL-2R is noisy. Figure S19. Behavior of the normalized number of total IL-2R (B + U).

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