Changes in prokaryotic TSPs due to systematic experimental mischaracterization of links. Original systems present a lower proportion of WCLs than the background in the set of links that connect nodes for which a secondary coherent regulatory pathway has been registered. In corrected networks, the proportion of WCLs is paired to background levels by randomly deleting poorly characterized interactions. This, however, do not affect the TSPs significantly.
Sanz et al. BMC Systems Biology 2012 6:110 doi:10.1186/1752-0509-6-110