Figure 7.

Simulations and lab results experiment #26. A: Reprint of figure 6D and E from [22] (License agreement number 2838800627526): Quantitative reverse transcription-PCR analysis of MITF target genes (c-Kit and TPH) and STAT3 target genes (c-Myc and VEGF) from BMMC activated for 0.5 or 4h with SCF derived from either wild-type or MITF^di/di mice. (B and C) Simulations of the same experiment (experiment #26 in Table 2). Note that the di/di mutation blocks the activation of both MITF and STAT3 in the reprinted lab result while in the simulation STAT3 activity is not affected.