Open Access Highly Accessed Research article

Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

Marc R Birtwistle1234, Jens Rauch2, Anatoly Kiyatkin3, Edita Aksamitiene3, Maciej Dobrzyński2, Jan B Hoek3, Walter Kolch2, Babatunde A Ogunnaike4* and Boris N Kholodenko23*

Author Affiliations

1 Dept. of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, 10029, USA

2 Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland

3 Dept. of Anatomy, Pathology, and Cell Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA

4 Dept. of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, 19716, USA

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BMC Systems Biology 2012, 6:109  doi:10.1186/1752-0509-6-109

Published: 24 August 2012

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