Nine types of changes in the flux patterns based on combinations of positive and negative changes inVavgandlsol. Types 1, 2, and 3 have the amplification candidates positively correlated with the production of a target chemical. Types 4, 5, and 6 were negatively correlated with the target product. Types 7, 8, and 9 did not show unique patterns with the enforced fluxes towards the target chemical. Nine possible combinations of flux bias ( Vavg) and flux capacity (lsol) for each reaction were investigated, and displayed on the bottom of the figure.
Park et al. BMC Systems Biology 2012 6:106 doi:10.1186/1752-0509-6-106