|The signals are more biologically meaningful than the noises|
|Test (with FDR = 0.05)||Test results|
|Functional enrichment||Our result has an equal or higher enrichment score than the noises in 94% (105/112) of the cases.|
|Expression coherence||Of the 112 TFs, 57% (64/112) show significantly higher expression coherence in the signals, compared with only 6% (7/112) in the noises.|
|The prevalence of protein-protein interactions||Of the 112 TFs, 82% (92/112) are enriched for membership to a protein-protein interaction module in the signals, compared with only 19% (21/112) in the noises|
To show that the signals are more biologically meaningful than the noises, we assessed the functional enrichment, the expression coherence, and the prevalence of protein-protein interactions. The signals outperform the noises across all measures.
Yang and Wu
Yang and Wu BMC Systems Biology 2012 6:102 doi:10.1186/1752-0509-6-102