Temporal profiles of macrophage numbers, IL-10 concentrations, and TGF-β concentrations post myocardial infarction establish the nonlinear dynamic patterns of the MI response. A: Temporal profile of macrophage infiltration (cell numbers/mm2) post myocardial infarction reconstructed from experimental data in C57 mice . B: Temporal profile of IL-10 concentrations (pg/ml) post myocardial infarction reconstructed from experimental data in C57 mice [19,20]. C: Temporal profile of TGF-β computed based on the nonlinear dynamics equation (24). D: Sampled TGF-β profile in part C to represent the sparse experimental data on TGF-β concentrations.
Ghasemi et al. BMC Systems Biology 2011 5(Suppl 3):S9 doi:10.1186/1752-0509-5-S3-S9