Table 2

Canonical pathways enriched with module genes by Ingenuity Pathway Analysis (IPA) (PBH < 10-6)

Ingenuity canonical pathways

Observed*

PBH$


cAMP-mediated signaling

23

6.31 × 10-16

G-protein coupled receptor signaling

31

5.01 × 10-15

Serotonin receptor signaling

12

6.31 × 10-15

Corticotropin releasing hormone signaling

14

7.94 × 10-11

Dopamine receptor signaling

11

3.80 × 10-9

Glucocorticoid receptor signaling

17

1.35 × 10-8

PXR/RXR activation

10

2.29 × 10-8

Amyotrophic lateral sclerosis signaling

11

5.89 × 10-8

Neuropathic pain signaling on dorsal horn neurons

11

5.89 × 10-8

Relaxin signaling

12

1.02 × 10-7

CREB signaling in neurons

13

1.62 × 10-7

Tryptophan metabolism

11

6.61 × 10-7


*Number of the observed DEPgenes in the category.

$P values were adjusted by Benjamini & Hochberg (BH) method [34].

Jia et al. BMC Systems Biology 2011 5(Suppl 3):S12   doi:10.1186/1752-0509-5-S3-S12

Open Data