Table 3

Genetic variants associated with highLDLhighTG

SNP

Chr

Base position

SNP type

gene

Str- and

Allele(+/-)

Freq (+)

P-value hLDLhTG

OR

mORPLDL

mORPTG

r2


rs11700112

20

9495018

nonsyn

PAK7

-

G

C

0.31

6.2×10-5

1.44

3.25

1.58

1.00

rs6140956

20

9450080

intronic

C20orf103

+

C

T

0.41

6.3×10-5

1.40

2.79

1.85

0.56

rs6133716

20

9455931

intronic

C20orf103

+

A

G

0.40

1.0×10-4

1.39

2.58

1.75

0.59

rs9967942

20

9503781

intronic

PAK7

-

C

A

0.34

9.6×10-5

1.41

3.24

1.76

0.89

rs11087847

20

9504159

intronic

PAK7

-

T

G

0.31

8.6×10-5

1.43

3.02

1.59

0.99

rs2822994

21

15282928

intronic

NRIP1

-

A

G

0.41

8.7×10-5

1.40

2.46

2.59

1.00

rs2822998

21

15285230

intronic

NRIP1

-

C

A

0.41

4.1×10-4

1.35

2.09

2.12

0.97

rs1041404

21

15346738

intronic

NRIP1

-

A

G

0.43

1.7×10-4

1.37

2.38

2.33

0.64

rs9959874

18

59045526

intronic

BCL2

-

A

G

0.15

1.2×10-4

1.60

3.40

2.20

1.00

rs1893506

18

59044660

intronic

BCL2

-

G

A

0.15

1.5×10-4

1.59

3.31

2.08

1.00

rs4744611

9

72551280

intronic

TRPM3

-

G

A

0.49

1.8×10-4

1.36

1.93

3.14

1.00

rs7039780

9

72469777

intronic

TRPM3

-

G

A

0.50

3.7×10-4

1.34

1.57

2.98

0.90

rs4744608

9

72470797

intronic

TRPM3

-

G

C

0.50

3.7×10-4

1.34

1.52

2.99

0.90

rs665770

1

200014747

intronic

NAV1

+

A

G

0.38

2.0×10-4

1.38

2.65

1.54

1.00

rs529581

1

200016143

intronic

NAV1

+

C

G

0.37

2.0×10-4

1.38

2.59

1.59

0.99

rs693

2

21085700

coding

APOB

-

A

G

0.07

7.3×10-4

1.83

0.04

2.21

-


SNP rs693 reported in a previous study (Kathiresan, et al, 2008) for associations between high TG and high LDL. The rs693 was pruned since its effect was stronger in single traits high LDL than multivariate highLDLhighTG with borderline significance.

Park et al. BMC Systems Biology 2011 5(Suppl 2):S13   doi:10.1186/1752-0509-5-S2-S13

Open Data