Figure 2.

Distribution of the SASA values (a), and distribution of the residue burial levels (b), in the hot spot and non hot spot residues. The two figures here show a comparison between the distribution of the values of two residue descriptors: SASA that is usually used in hot spot prediction, and burial level that is proposed by us, in hot spot and non hot spot residues. In (a), the distribution of SASA is shown, in which we can find that both the number of hot spots and the number of non hot spots go down as SASA gets larger. In (b), as the burial level gets larger, the number of non hot spot residues drops while the number of hot spot residues goes up.