TF-regulatory gene expression networks in 16-20w WKY (A) and GK (B). The node color and form are drawn by the same way as Figures 1 and 5, respectively. Nuclear receptors play important role maintaining the non-diabetic stage in WKY strain. In GK rats, some compensational pathways still exist. However, genes involved in insulin resistance, hypertension and apoptosis are able to cause diabetes progression.
Zhou et al. BMC Systems Biology 2011 5(Suppl 1):S16 doi:10.1186/1752-0509-5-S1-S16