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This article is part of the supplement: Selected articles from the 4th International Conference on Computational Systems Biology (ISB 2010)

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A trigger model of apoptosis induced by tumor necrosis factor signaling

Chang Gu1, Junjie Zhang2, Yingyu Chen34 and Jinzhi Lei5*

Author Affiliations

1 School of Mathematical Sciences, Peking University, Beijing 100871, China

2 The Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China

3 Laboratory of Medical Immunology, School of Basic Medical Science, Health Science Center, Peking University, 38 Xueyuan Road, Beijing 100083, China

4 Center for Human Disease Genomics, Peking University, 38 Xueyuan Road, Beijing 100083, China

5 Zhou Pei-Yuan Center for Applied Mathematics, Tsinghua University, Beijing 100084, China

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BMC Systems Biology 2011, 5(Suppl 1):S13  doi:10.1186/1752-0509-5-S1-S13

Published: 20 June 2011

Additional files

Additional file 1:

Experimental result of Jurkat cells apoptosis induced with TRAIL.

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Additional file 2 :

Simulation results of the dependence of resistance and effective coefficients to the activation efficiencies of caspase-8 and caspase-3.

Format: PDF Size: 66KB Download file

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