Model of Action of c-Myc, E2F1 and 14-3-3ζ. Model of the downstream events product of the overexpression and/or amplification of c-Myc, and its collaboration with the transcription factor E2F1. c-Myc promotes the expression of proteins that lead to survival and proliferation through processes such as metabolism, protein biosynthesis and transcription factors. Likewise, it enables the expression of proteins involved in epithelial mesenchymal transition. E2F1 and c-Myc work together to promote the expression of Cyclins and E2F factors that boost the transition between G1 and S phases of mitosis, as well as the expression of 14-3-3ζ and Bcl-2. Bcl-2 is an antiapoptotic protein that prevents the release of cytochrome c. The overexpression of 14-3-3ζ results in instability and degradation of p53, increased cell proliferation, and cytoplasmic sequestration of BAD with what brings drastic decrease of apoptosis.
Higareda-Almaraz et al. BMC Systems Biology 2011 5:96 doi:10.1186/1752-0509-5-96