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## Figure 7.
Analysis of drug combination differential responses. The figure presents the analysis results to identify combinations of drugs that
can maximize a performance function reflecting the desired objective of minimizing
the killing of AG02603 cells and maximizing the killing of A549 cels (see methods
section for the details on the performance functions. (A) Results of k-means clustering
analysis of the performance of four-drug combinations. Points are grouped together
to minimize the distance to the mean of that group. Each group is given a identification
number (ID). The x-axis shows cluster IDs; the y-axis shows the performance score
of each drug combination. The heat map is a function of the performance for each point.
(B) Cell ATP-level (x-axis: AG02603; y-axis: A549) upon four-drug combination treatments.
The red stars represent the experimentally tested 148 drug combinations. The squares
represent the whole set of 2401 possible drug combinations with the heat map colors
reflecting the performance of each combination.
Al-Shyoukh |