Resolution:
## Figure 1.
Summary of approach. (A) The proposed approach uses input-output data to generate mathematical models
capable of predicting the cellular responses to input combinations. The models enable
using other mathematical tools for analyzing the cellular responses and for selecting
the appropriate combinations of the input signal to drive the system to respond favorably.
(B) The desired drugs are combined in certain concentrations and a few combinations
are chosen and evaluated experimentally. A predictive mathematical model is generated
that can predict the response to all possible combinations. The model can be used
to analyze and predict drug interactions and their effects on the observed cellular
response and can also be used to determine effective combinations.
Al-Shyoukh |