The shape of the computed epigenetic landscape can be altered by modifying gene interaction parameters. When basal expression By of gene y in the tristable two-gene system (see Methods) is increased from By = 0 (A) to By = 4 (B) (dimensionless units), attractor A on the landscape is "lowered" relative to attractor B, causing cells to "roll into" the more stable state A from the destabilized state B. Numbers on the figure refer to the percentage of stochastically simulated cells in the respective attractors. All simulations were started from state B as the initial condition, and run to time t = 10,000. Hill coefficient nH = 10 in both figures.
Bhattacharya et al. BMC Systems Biology 2011 5:85 doi:10.1186/1752-0509-5-85