Candidate drug targets. The figure contains all predicted synthetic lethal interactions for STM_v1.0 in LB medium. A line connecting two genes represents a synthetic lethal pair. A group of genes surrounded by a dashed box represents a protein complex requiring all enclosed elements to function. Yellow background means associated with sulfur metabolism. Blue background indicates that the synthetic lethal pairs are functional homolog's. Red gene means that there is a chemical known to inhibit the gene-product in STM_v1.0.
Thiele et al. BMC Systems Biology 2011 5:8 doi:10.1186/1752-0509-5-8