Approach to reconcile two metabolic reconstructions (MR). This figure illustrates the automated comparison tool developed for the Salmonella reconstruction jamboree. Both MRs are translated into a common language (based on KEGG ). Metabolites and reactions that could not be mapped onto KEGG were subject to manual evaluation by the jamboree team. The overlapping part of the MRs was directly moved into the consensus MR while reactions and metabolites unique to a MR were evaluated manually. This approach can be readily applied to comparison of any two MRs.
Thiele et al. BMC Systems Biology 2011 5:8 doi:10.1186/1752-0509-5-8